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Migration inducting gene 7
Migration inducting gene 7 (Mig-7 or Mig7) is a gene. The protein is cysteine-rich, and localized to the cell membrane and cytoplasm.〔 It is the first-in-class of novel proteins translated from what are thought to be long Non-coding RNAs.
Induction of Mig-7 expression occurs downstream of Epidermal growth factor/Epidermal growth factor receptor, Cox-2/PGE-2 or Hepatocyte growth factor/c-Met activation and signalling. Data has shown that Mig-7 expression is specific to human embryonic/fetal cytotrophoblast cells〔 and epithelial type cancer cells, while not expressed in normal cells.〔〔〔〔 Data demonstrate that targeting of Mig-7 simultaneously inhibits more than one cancer-progressing pathway while likely sparing normal cells.〔〔〔〔〔
==Expression==
Mig-7 expression is found on, as well as in, epithelial tumor cells at the primary site, secondary (metastatic) sites, and blood from cancer patients. It is not produced by cells of normal human tissues or by cells from patients with inflammation but is expressed by epithelial precancerous and malignant cells.〔〔〔〔 It is also expressed in fetal/embryonic cytotrophoblast cells of early placenta.〔〔
Mig-7 expression increases in malignant cancers. There is a high sensitivity and specificity of Mig-7 detection in breast (98% n=48 of 49), uterine (100% n=49), gastric (94.5% n=104 of 110) and lung (100% n=89) cancers.〔〔〔〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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